Editorial overview: Roseoloviruses: stopping to smell the roses--the Roseoloviruses have come of age as human pathogens.

نویسنده

  • Laurie T Krug
چکیده

Four human herpesviruses were discovered in a eight-year period between 1986 and 1994. This exciting era of virus discovery was driven in part by the search for HIV and HIV-related diseases coupled with the development of new molecular tools such as PCR, automated Sanger sequencing, and subtractive hybridization. Three of these viruses, human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B), and human herpesvirus 7 (HHV-7), were initially cultured from peripheral blood mononuclear cells. All three were found to be T lymphotropic viruses that were most closely related to human cytomegalovirus (HCMV), placing them in the betaherpesvirus family. Given their tight biologic and genetic relationships and clear etiologic link to roseola infantum, these viruses are now designated Roseoloviruses. Human herpesvirus 8 (also known as Kaposi’s sarcoma associated herpesvirus) was identified as a new member of the gammaherpesviruses, in the rhadinovirus genus. Given its clear link to HIV-related malignancies, HHV-8 research exploded.

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عنوان ژورنال:
  • Current opinion in virology

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2014